PUBLICATIONS

2021

 

In their new study published in Cell Chemical Biology, the Bhatia group has identified a compound (McM25044) capable of selectively inhibiting human CSC function versus normal stem cell counterparts. Biochemical and molecular studies revealed that McM025044 exerts inhibition on human CSCs through the small ubiquitin-like modifier (SUMO) cascade, found to be hyperactive in a variety of human cancers. McM025044 impedes the SUMOylation pathway via direct targeting of the SAE1/2 complex. Treatment of patient-derived CSCs resulted in reduced levels of SUMOylated proteins and suppression of progenitor and stem cell capacity measured in vitro and in vivo. Their study overcomes a barrier in chemically inhibiting oncogenic SUMOylation activity and uncovers a unique role for SAE2 in the biology of human cancers.

Nature Communications, 2014

SOMATIC TRANSCRIPTOME PRIMING GATES LINEAGE-SPECIFIC DIFFERENTIATION POTENTIAL OF HUMAN-INDUCED PLURIPOTENT STEM CELL STATES

Jong-Hee Lee, Jung Bok Lee, Zoya Shapovalova, Aline Fiebig-Comyn, Ryan R. Mitchell, Sarah Laronde, Eva Szabo, Yannick D. Benoit & Mickie Bhatia

Cell Stem Cell, 2013

REGIONAL LOCALIZATION WITHIN THE BONE MARROW INFLUENCES THE FUNCTIONAL CAPACITY OF HUMAN HSCS

Guezguez B, Campbell CJ, Boyd AL, Karanu F, Casado FL, Di Cresce C, Collins TJ, Shapovalova Z, Xenocostas A, and Bhatia M

Cell, 2012

IDENTIFICATION OF DRUGS INCLUDING A DOPAMINE RECEPTOR ANTAGONIST THAT SELECTIVELY TARGET CANCER STEM CELLS

Sachlos E, Risueno R, Laronde S, Shapovalova Z, Lee JH, Russell J, Malig M, McNicol JD, Fiebig-Comyn A, Graham M, Levadoux-Martin M, Lee JB, Giacomelli AO, Hassell JA, Fischer- Russell D, Trus MR, Foley R, Leber B, Xenocostas A, Browne ED, Collins T, and Bhatia M

Nature Cell Biology, 2017

ACUTE MYELOID LEUKEMIA DISRUPTS ENDOGENOUS MYELO-ERYTHROPOIESIS BY COMPROMISING THE ADIPOCYTE BONE MARROW NICHE

Boyd AL, Reid JC, Salci KR, Aslostovar L, Benoit YD, Shapovalova Z, Nakanishi M, Porras DP, Almakadi M, Campbell CJV, Jackson MF, Ross CA, Foley R, Leber B, Allan DS, Sabloff M, Xenocostas A, Collins TJ, and Bhatia M

Cancer Cell 2016

GSK3 DEFICIENCIES IN HEMATOPOIETIC STEM CELLS INITIATE PRE-NEOPLASTIC STATE THAT IS PREDICTIVE OF CLINICAL OUTCOMES OF HUMAN ACUTE LEUKEMIA

Guezguez B, Almakadi M, D Benoit YD, Shapovalova Z, Rahmig S, Fiebig-Comyn A, Casado FL, Tanasijevic B, Bresolin S, Masetti R, Doble BW, Bhatia M

Cell Reports, 2015

SINGLE TRANSCRIPTION FACTOR CONVERSION OF HUMAN BLOOD FATE TO NPCS WITH CNS AND PNS DEVELOPMENTAL CAPACITY

Lee JH, Mitchell RR, McNicol JD, Shapovalova Z, Laronde S, Tanasijevic B, Milsom C, Casado F, Fiebig-Comyn A, Collins TJ, Singh KK, and Bhatia M

Cell, 2019

HUMAN PLURIPOTENCY IS INITIATED AND PRESERVED BY A UNIQUE SUBSET OF FOUNDER CELLS

Mio Nakanishi, Ryan R. Mitchell, Yannick D. Benoit, Luca Orlando, Jennifer C. Reid, Kenichi Shimada, Kathryn C. Davidson, Zoya Shapovalova, Tony J. Collins, Andras Nagy, Mickie Bhatia

Cancer Cell, 2018

Allison Boyd*, Lili Aslostovar*, Jennifer Reid, Wendy Ye, Borko Tanasijevic, Deanna Porras, Zoya Shapovalova, Mohammed Almakadi, Ronan Foley, Brian Leber, Anargyros Xenocostas, Mickie Bhatia
*indicates co-lead authors

IDENTIFICATION OF CHEMOTHERAPY-INDUCED LEUKEMIC REGENERATING CELLS REVEALS A TRANSIENT VULNERABILITY OF HUMAN AML RECURRENCE

Cell Stem Cell, 2011

CELL FATE POTENTIAL OF HUMAN PLURIPOTENT STEM CELLS IS ENCODED BY HISTONE MODIFICATIONS

Seok-Ho Hong, Shravanti Rampalli, Jung Bok Lee, Jamie McNicol, Tony Collins, Jonathan S Draper, Mickie Bhatia

Nature, 2010

DIRECT CONVERSION OF HUMAN FIBROBLASTS TO MULTILINEAGE BLOOD PROGENITORS

Eva Szabo, Shravanti Rampalli, Ruth M Risueño, Angelique Schnerch, Ryan Mitchell, Aline Fiebig-Comyn, Marilyne Levadoux-Martin, Mickie Bhatia

Nature Biotechnology, 2009

CHARACTERIZATION OF HUMAN EMBRYONIC STEM CELLS WITH FEATURES OF NEOPLASTIC PROGRESSION

Tamra E Werbowetski-Ogilvie, Marc Bossé, Morag Stewart, Angelique Schnerch, Veronica Ramos-Mejia, Anne Rouleau, Tracy Wynder, Mary-Jo Smith, Steve Dingwall, Tim Carter, Christopher Williams, Charles Harris, Joanna Dolling, Christopher Wynder, Doug Boreham, Mickie Bhatia

Stem Cells, 2008

OP9 STROMA AUGMENTS SURVIVAL OF HEMATOPOIETIC PRECURSORS AND PROGENITORS DURING HEMATOPOIETIC DIFFERENTIATION FROM HUMAN EMBRYONIC STEM CELLS

Junfeng Ji, Kausalia Vijayaragavan, Marc Bosse, Pablo Menendez, Katja Weisel, Mickie Bhatia

Nature, 2007

IGF AND FGF COOPERATIVELY ESTABLISH THE REGULATORY STEM CELL NICHE OF PLURIPOTENT HUMAN CELLS IN VITRO

Sean C Bendall, Morag H Stewart, Pablo Menendez, Dustin George, Kausalia Vijayaragavan, Tamra Werbowetski-Ogilvie, Veronica Ramos-Mejia, Anne Rouleau, Jiabi Yang, Marc Bossé, Gilles Lajoie, Mickie Bhatia

Nature Medicine, 2006

GLYCOGEN SYNTHASE KINASE-3 IS AN IN VIVO REGULATOR OF HEMATOPOIETIC STEM CELL REPOPULATION

Jennifer J Trowbridge, Anargyros Xenocostas, Randall T Moon, Mickie Bhatia

SELECTED PUBLICATIONS

COVER ART

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Aslostovar L, Boyd AL, Benoit YD, Lu JD, Rodriguez JLG, Nakanishi M, Porras DP, Reid JC, Mitchell RR, Leber B,  Xenocostas A, Foley R, and Bhatia M